Give your patients rejuvenated vision by reducing spherical aberration to 0.0*

Peak visual performance occurs at age 19, when the average spherical aberration is 0.0 microns.¹ As spherical aberration increases with age, contrast sensitivity decreases.² Cataract surgery is a once-in-a-lifetime opportunity to reverse this effect and TECNIS™ is the only aspheric IOL designed to reduce spherical aberration to 0.0, and bring back youthful vision similar to that of a 19-year old.^1,3,4

To learn more about the innovative TECNIS™ IOL, available in both hydrophobic acrylic and silicone materials, please explore the topics on this site.

*Based on average cataract patient

TECNIS™ IOLs are the FIRST and ONLY wave-front designed IOLs with claims approved by the FDA for:

• Reduced spherical aberration³
• Improved functional vision³
• Improved night driving simulator performance³

The TECNIS™ IOL reduced spherical aberration to essentially zero³

A clinical study showed that the average ocular spherical aberration of TECNIS™ IOL eyes was not significantly different from zero.³

Total Ocular Spherical Aberration of TECNIS IOL Eyes is Not Significantly Different From Zero3

Mean Spherical Aberration Measurements, 90±15 Days Postoperatively, Study 001: Z9000: N=25; Lens with Spherical Optic: N=243

Improved Functional Vision

TECNIS™ IOLs are likely to provide a meaningful safety benefit to elderly drivers^3,10

In a simulated night-driving study, at 55 mph the TECNIS™ Lens provided an additional 45 feet of identification distance, allows for a second of additional reaction time, when compared to a leading competitor.3

• In the study, the TECNIS™ lens improved the identification distance for a pedestrian hazard by 45 feet compared to a traditional spherical lens implant³
• At 55 mph, the 45-foot increase in visibility with the TECNIS™ lens allows for an additional half-second (0.50 second) to perceive and react to a driving hazard compared to a traditional spherical lens implant^3,10
• In comparison, the addition of the center high-mounted brake lights only improved driver reaction time by 0.35 seconds¹⁰

Best possible vision targets zero spherical aberration

To rejuvenate vision to youthful levels, it is necessary reduce or eliminate spherical aberration. Other intraocular lenses provide excellent visual acuity but fail to properly address the increase in spherical aberration that occurs with age, leaving vision like that of an eye of a healthy older person. Only TECNIS™ IOL is designed to reduce spherical aberration to zero, restoring vision like that of a 19-year old.^1,4

On the average, the young eye has zero spherical aberration^1,11-15

• Peak visual performance occurs at age 19; this is when contrast sensitivity and quality of vision peak^1,11-15
• The negative spherical aberration of the young crystalline lens balances the positive spherical aberration of the cornea⁶
• Light on the retina is sharply focused, producing a high-quality, sharp image

With age, spherical aberration increases, reducing functional vision^6,16

• The aging crystalline lens loses its ability to compensate for positive corneal spherical aberration
• Spherical aberration causes diffusion of light resulting in blurred vision, reduced contrast sensitivity, and decreased functional vision
• Patients with decreased functional vision may lack confidence in low-light situations or have difficulty with night driving or glare¹⁷

The TECNIS™ IOL reduces spherical aberration for improved functional vision

• Wavefront aberration analysis confirms that the average cornea of a cataract patient has +0.27 microns of spherical aberration throughout life¹⁸
• The TECNIS™ IOL corrects for -0.27 microns of spherical aberration¹⁸, just like the average crystalline lens did between the ages of 19-25
• Clinical data submitted to the FDA showed that the TECNIS™ IOL provides a significant improvement in functional vision³

Zero spherical aberration means peak visual performance^1,11-15

Other IOLs (both spherical and aspheric) are designed to leave positive spherical aberration. The result is a diffusion of the light reaching the retina and a reduction in contrast sensitivity.

Residual Spherical Aberration (SA) of Monofocal Lenses (4 mm pupil)16

*Images simulated using ZernikeTool, created by George Dai, PhD. †The point spread function (PSF) is the shape of a single, concentrated ray of light as it is projected through a lens. PSF is used to describe the distortion caused by aberrations present in an optical system. ††SA correction of lens at corneal plane.

TECNIS™ IOL demonstrates increased contrast sensitivity in numerous clinical studies^7,9,18-22

TECNIS™ IOL increased contrast sensitivity an average of 33% over a variety of control lenses (P < .0001).¹⁸

A prospective clinical study measured contrast sensitivity at varying light levels with three different IOLs including the TECNIS™ IOL with a wavefront-designed surface and the AcrySof™ Natural SN60AT blue-blocking IOL. The TECNIS™ IOL demonstrated a statistically significant improvement in mean contrast sensitivity in 19 out of 20 combinations of light levels and spatial frequencies.¹⁹

Photopic contrast sensitivity (without glare)19

Mesopic contrast sensitivity (without glare)19

The TECNIS™ IOL shows significant improvement in Modulation Transfer Function (MTF) compared to other aspheric lenses

In one study, the TECNIS™ IOL shows over twice the improvement in MTF at 100 c/mm versus AcrySof™ IQ SN60WF and over three times the improvement in MTF at 100 c/mm versus LI61AO and Canon Staar KS-3Ai.¹⁸ In fact, LI61AO performs similarly to a spherical lens.

MTF Comparison of Lens Models (5 mm pupil)18

Modulation transfer function (MTF) measures the ability of an optical system to transfer contrast. The higher the MTF on the graph above, the higher percentage of contrast the lens is transferring for a given image. (*Average Cornea Eye model)

1. Artal P, Alcón E, Villegas E. Spherical aberration in young subjects with high visual acuity. Presented at: XXIV Congress of the European Society of Cataract and Refractive Surgeons; September 9-13, 2006; London, England.
2. Artal P, Berrio E, Guirao A, Piers P. Contribution of the cornea and internal surfaces to the change of ocular aberrations with age. J Opt Soc Am A Opt Image Sci Vis. 2002;19(1):137-143.
3. Package insert. TECNIS™ Foldable Posterior Chamber Intraocular Lens. Advanced Medical Optics, Inc.
4. Packer M, Fine IH, Hoffman RS. Functional vision, wavefront sensing, and cataract surgery. Int Ophthalmol Clin. 2003;43(2):79-91.
5. Holladay JT, Piers PA, Koranyi G, et al. A new intraocular lens design to reduce spherical aberration of pseudophakic eyes. J Refract Surg. 2002;18:683-691.
6. Guirao A, Tejedor J, Artal P. Corneal aberrations before and after small-incision cataract surgery. Invest Ophthalmol Vis Sci. 2004;45(12):4312-4319.
7. Mester U, Dillinger P, Anterist N. Impact of a modified optic design on visual function: clinical comparative study. J Cataract Refract Surg. 2003;29(4):652-660.
8. Wang L, Dai E, Koch DD, Nathoo A. Optical aberrations of the human anterior cornea. J Cataract Refract Surg. 2003;29(8):1514-1521.
9. Bellucci R, Scialdone A, Buratto L, et al. Visual acuity and contrast sensitivity comparison between Tecnis and AcrySof SA60AT intraocular lenses: a multicenter randomized study. J Cataract Refract Surg. 2005;31(4):712-717.
10. McBride DK, Matson W. Assessing the significance of optically produced reduction in braking response time: possible impacts on automotive safety among the elderly. Potomac Institute for Policy Studies. April 1, 2003.
11. Glasser A, Campbell MC. Presbyopia and the optical changes in the human crystalline lens with age. Vision Res. 1998;38:209-229.
12. Smith G, Cox MJ, Calver R, et al. The spherical aberration of the crystalline lens of the human eye. Vision Res. 2001;41(2):235-243.
13. Guirao A, Gonzalez C, Redondo M, et al. Average optical performance of the human eye as a function of age in a normal population. Invest Ophthalmol Vis Sci.1999;40(1):203-213.
14. Wang L, Koch D. Ocular higher-order aberrations in individuals screened for refractive surgery. J Cataract Refract Surg. 2003;29(10);1896-1903.
15. Holzer M, Auffarth G. Data presented at the DOC 2006.
16. Oshika T, Klyce SD, Applegate RA, et al. Changes in corneal wavefront aberrations with aging. Invest Ophthalmol Vis Sci. 1999;40:1351-1355.
17. Scilley K, Jackson GR, Owsley C, et al. Early age-related maculopathy and self-reported visual difficulty in daily life. Ophthalmol. 2002;109:1235-42.
18. Data on file, Advanced Medical Optics, Inc.
19. Kennis H, Huygens M, Callebaut F. Comparing the contrast sensitivity of a modified prolate anterior surface IOL and of two spherical IOLs. Bull Soc Belge Ophtalmol. 2004;294:49-58.
20. Packer M, Fine IH, Hoffman RS, Piers PA. Prospective randomized trial of an anterior surface modified prolate intraocular lens. J Refract Surg. 2002;18(6):692-696.
21. Kershner RM. Retinal image contrast and functional visual performance with aspheric, silicone, and acrylic intraocular lenses. Prospective evaluation. J Cataract Refract Surg. 2003;29(9):1684-1694.
22. Martinez Palmer A, Palacin Miranda B, Castilla Cespedes M, et al. [Spherical aberration influence in visual function after cataract surgery: prospective randomized trial.] Arch Soc Esp Oftalmol. 2005;80(2):71-78. Spanish language.
23. Buell W, Menapace R, Sacu S, et al. Effect of a silicone intraocular lens with a sharp posterior edge on posterior capsule opacification. J Cataract Refract Surg. 2004;30:1661-1667.

TECNIS™ IOLs Recognized for Superior Performance With NTIOL Designation*

The clinical benefits of TECNIS™ IOLs are well-documented in numerous published, peer-reviewed articles. In fact, it is the only wavefront-designed IOL with claims approved by the FDA for reduced spherical aberration, improved functional vision and improved performance in a night-driving simulator study.³

Recognizing the significant performance benefits of TECNIS™ IOLs, the Centers for Medicare and Medicaid Services (CMS) announced on January 26, 2006, that TECNIS™ IOLs have been granted New Technology IOL (NTIOL) designation. This designation allows for additional reimbursement for TECNIS™ IOLs implanted in an Ambulatory Surgery Center (ASC).

Click here to read the CMS press release for TECNIS™ NTIOLs.

With substantial proof of "specific clinical advantages and superiority over existing IOLs" a new NTIOL category for incremental reimbursement was established specifically for TECNIS™ IOLs — Reduced Spherical Aberration. This recognition further emphasizes the unique benefits and advantages of TECNIS™ wavefront-designed IOLs.

For more information regarding Medicare, billing and practice implementation, refer to the Corcoran Consulting Group Web site or call Kevin Corcoran at (800) 399-6565.

* Medicare News. CMS Announces Approval of New Technology Intraocular Lens. CMS Office of Media Affairs. January 26, 2006.

TECNIS™ Acrylic IOL ZA9003

Hydrophobic acrylic and next-generation silicone TECNIS™ IOLs offer:

• Designed to reduce spherical aberration to 0.0 microns
• Full transmission of visible light
• Effective UV protection
• Vacuole-free material
• Proven biocompatibility²⁰

References:

1. SRK/T
2. Holladay I
3. Values published at User Group for Laser Interference Biometry (http://www.augenklinik.uni-wuerzburg.de/ulib/c1.htm). Maintained by Wolfgang Haigis PhD, University Eye Hospital Wuerzburg (w.haigis@augenklinik.uni-wuerzburg.de). Last updated June 27, 2007. TECNIS™ CL IOL Z9002 constants based on sample size 185 patients. For best results, constants should be personalized.
4. Hoffer Q
5. Data on file, Advanced Medical Optics, Inc.
6. Value theoretically derived for a typical 20.0 D lens.

TECNIS™ CL Silicone IOL Z9002

Hydrophobic acrylic and next-generation silicone TECNIS™ IOLs offer:

• Designed to reduce spherical aberration to 0.0 microns
• Full transmission of visible light
• Effective UV protection
• Vacuole-free material
• Proven biocompatibility²⁰

References:

1. SRK/T
2. Holladay I
3. Values published at User Group for Laser Interference Biometry (http://www.augenklinik.uni-wuerzburg.de/ulib/c1.htm). Maintained by Wolfgang Haigis PhD, University Eye Hospital Wuerzburg (w.haigis@augenklinik.uni-wuerzburg.de). Last updated June 27, 2007. TECNIS™ CL IOL Z9002 constants based on sample size 185 patients. For best results, constants should be personalized.
4. Hoffer Q
5. Data on file, Advanced Medical Optics, Inc.
6. Value theoretically derived for a typical 20.0 D lens.

For consumer information on TECNIS® IOLs please visit

http://www.tecnisiol.com